Реакция #1544479

Уравнение реакции

2-Bromo-5-phenyl-1,3,4-thiadiazole

1-octylmagnesium bromide

→

2-Octyl-5-phenyl-1,3,4-thiadiazole

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONdissolved in
2. 2
   workup.ADDITION, is then added dropwise at -5° C
3. 3
   ДругоеAfter acidification by means of hydrochloric acid (pH=2), the organic phase is separated off
4. 4
   Другоеevaporated
5. 5
   ДругоеThe crude product is recrystallized from acetonitrile

Методика

2-Bromo-5-phenyl-1,3,4-thiadiazole (2.9 g, 12 mmol) is added to a 1-octylmagnesium bromide solution (4.6 g, 24 mmol) in THF (80 ml) under a protective-gas atmosphere, and 1,3-bis(diphenylphosphino)propylnickel(II) chloride (0.15 mmol), dissolved in . . . , is then added dropwise at -5° C. The mixture is subsequently stirred at this temperature for 4 hours. After acidification by means of hydrochloric acid (pH=2), the organic phase is separated off and evaporated. The crude product is recrystallized from acetonitrile.

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