Реакция #1542

Уравнение реакции

2-phenyl-6-trifluoromethyl-4(3H)-pyrimidinone

N-bromosuccinimide

→

5-bromo-2-phenyl-6-trifluoromethyl-4(3H)-pyrimidinone

Выход 83.5%

Растворители

acetic

Условия реакции

Обработка

1. 1
   workup.WAITthe mixture was left
2. 2
   workup.ADDITIONThe reaction was poured onto ice water and vacuum
3. 3
   Фильтрацияfiltered
4. 4
   Промывкаwashing well with water
5. 5
   ДругоеThe crude product was recrystallized from ethyl acetate

Методика

To a solution of 1.0 g (3.94 mmol) of 2-phenyl-6-trifluoromethyl-4(3H)-pyrimidinone and 20 mL of glacial acetic add was added 1.0 g (5.6 mmol) N-bromosuccinimide and the mixture was left to stir at room temperature for 16 h. The reaction was poured onto ice water and vacuum filtered, washing well with water. The crude product was recrystallized from ethyl acetate to yield 1.05 g (83.5%) of 5-bromo-2-phenyl-6-trifluoromethyl-4(3H)-pyrimidinone, as a white solid. 1H-NMR (d6DMSO) δ 7.6(3H,m); 8.15(2H,m).

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