Реакция #1537

Уравнение реакции

N-t-butyl-3-(1-acetoxy-2-chloroethyl)-2-thiophenesulfonamide

→

pure title compound

Выход 72.0%

3-(1-acetoxy-2-chloroethyl)-2-thiophenesulfonamide

Выход 72.0%

Растворители

trifluoroacetic acid

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methylene chloride
3. 3
   Промывкаthe solution was washed with aqueous sodium bicarbanate solution
4. 4
   ДругоеThe organic layer was separated
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   Фильтрацияfiltered
7. 7
   КонцентрированиеThe filtrate was then concentrated

Методика

1.5 g (0.0044 mole) of N-t-butyl-3-(1-acetoxy-2-chloroethyl)-2-thiophenesulfonamide synthesized in Example 7 was dissolved in 5 ml of trifluoroacetic acid. The reaction solution was stirred at normal temperature for 12 hours and then concentrated under reduced pressure. The residue was dissolved in methylene chloride and the solution was washed with aqueous sodium bicarbanate solution. The organic layer was separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was then concentrated. The residue was subjected to column chromatograpy on silica gel to obtain 760 mg (Yield: 72%) of the pure title compound.

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