Реакция #1524

Уравнение реакции

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

Условия реакции

Обработка

1. 1
   ДругоеAfter completion of the reaction
2. 2
   Экстракцияthe resultant mixture was extracted with ether
3. 3
   Промывкаwashed with water, which
4. 4
   Промывкаwas further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   Промывкаwashed again with water
7. 7
   КонцентрированиеThe reaction product was concentrated
8. 8
   Другоеseparated by colomun chromatography

Методика

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

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