Реакция #1521418

Уравнение реакции

pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone

→

title compound

Выход 57.1%

6-{2-{{4-[2-(7-Azabicyclo[2.2.1]hept-7-yl)ethoxy]benzyl}methylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

Выход 57.1%

Условия реакции

Обработка

1. 1
   Другоеpurified by LC-MS

Методика

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-bromoethanone (22 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (15 mg) was obtained.

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