Реакция #1519125

ord-b5aeb1364c414142b2de1e16b42226e1

Уравнение реакции

c1ccc(C2CCNC2)nc1
2-pyrrolidin-3-yl-pyridine
CCCCC(C(=O)O)C1OC(C)(C)OC1=O
2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid
→
CCCC[C@@H](C(=O)N1CCC(c2ccccn2)C1)[C@H](O)C(=O)O
title compound
CCCC[C@@H](C(=O)N1CCC(c2ccccn2)C1)[C@H](O)C(=O)O
(S)-hydroxy-3 (R)-[3 (R/S)-pyridin-2-yl-pyrrolidine-1-carbonyl)-heptanoic acid

Реактанты

c1ccc(C2CCNC2)nc1
2-pyrrolidin-3-yl-pyridine
CCCCC(C(=O)O)C1OC(C)(C)OC1=O
2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound is prepared from 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5 and commercially available 2-pyrrolidin-3-yl-pyridine A-5 according to General Procedure B.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07612059B2uspto-grants-2009_11