Реакция #1519121

Уравнение реакции

TMSCl

1H-1,2,3-triazole

→

TMS-triazole

Растворители

benzene

benzene

Условия реакции

Обработка

1. 1
   ДругоеReaction mixture
2. 2
   ДругоеThe resultant precipitate is removed by filtration
3. 3
   Промывкаwashed thoroughly with dry benzene
4. 4
   КонцентрированиеThe filtrate is gently concentrated
5. 5
   Другоеto avoid evaporating the highly volatile product

Методика

To a solution of 1H-1,2,3-triazole (4.98 g, 72.10 mmol, 1 equiv.) in dry benzene (145 mL) at rt under nitrogen, is added TEA (11.05 mL, 79.31 mmol, 1.1 equiv.) followed by the dropwise addition of TMSCl (9.15 mL, 72.10 mmol, 1 equiv.). A white precipitate develops. Reaction mixture is stirred at rt under nitrogen for 1 hour. The resultant precipitate is removed by filtration and washed thoroughly with dry benzene. The filtrate is gently concentrated to avoid evaporating the highly volatile product to give a quantitative yield of TMS-triazole with a trace of benzene.

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