Реакция #1519117

Уравнение реакции

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

NaOH

HCl

→

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

Растворители

MeOH

water

Условия реакции

Обработка

1. 1
   Другоеthe MeOH is removed
2. 2
   Другоеthe crude reaction
3. 3
   Экстракцияextracted with EtOAc (3×50 mL)
4. 4
   СушкаThe combined organic layers are dried (Na2SO4)
5. 5
   Концентрированиеconcentrated

Методика

To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.

Источник