Реакция #1519107

Уравнение реакции

ammonium chloride

4-chloro-2-cyanopyridine

sodium methoxide

→

2-amidino-4-chloropyridine hydrochloride

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураrefluxing
2. 2
   ДругоеThe volatile components are then removed in vacuo

Методика

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

Источник