Реакция #1519

Уравнение реакции

2-(4-decyloxyphenyloxycarbonyl)-1,2,3,4-tetrahydro-6-benzyloxynaphthalene

hydrogen

→

2-(4-decyloxyphenyloxycarbonyl)-1,2,3,4-tetrahydro-6-hydroxynaphthalene

Выход 97.7%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Другое5% palladium/carbon was removed
2. 2
   Концентрированиеthe filtrate was concentrated
3. 3
   ДругоеThe concentrate obtained
4. 4
   Другоеwas purified by column chromatography
5. 5
   Другоеto obtain

Методика

Then, 0.04 g of 5% palladium/carbon and 10 ml of a tetrahydrofuran solution containing 0.36 g of 2-(4-decyloxyphenyloxycarbonyl)-1,2,3,4-tetrahydro-6-benzyloxynaphthalene were stirred overnight at room temperature in a stream of hydrogen to decompose a benzyl protective group by hydrogenation. 5% palladium/carbon was removed using Celite as a filter aid, and the filtrate was concentrated. The concentrate obtained was purified by column chromatography to obtain 0.29 g of 2-(4-decyloxyphenyloxycarbonyl)-1,2,3,4-tetrahydro-6-hydroxynaphthalene as a white crystal (isolated yield: 97%).

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