Реакция #1509597

Уравнение реакции

dimethylamine

2-Chloro-6-methyl-isonicotinic acid

DIPEA

TBTU

→

title compound

2-Chloro-6,N,N-trimethyl-isonicotinamide

Растворители

water

DMF

Условия реакции

Обработка

1. 1
   Экстракцияextracted with EtOAc
2. 2
   ДругоеThe organic layer was separated
3. 3
   Другоеdried
4. 4
   Концентрированиеconcentrated in vacuum

Методика

To a solution of 2-Chloro-6-methyl-isonicotinic acid (1 g) in DMF (200 ml) at 25° C. was added DIPEA (2.9 mL) and TBTU (1.8 ml). After 5 min, dimethylamine (0.75 g) was added dropwise. This was stirred overnight. The reaction was added to water and extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash:chromatography (9:1 to 2:8 gradient cyclohexane:EtOAc) afforded the title compound (320 mg). Rf=0.56 (1:1 cyclohexane:EtOAc)

Источник