Реакция #1509588

Уравнение реакции

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate

TFA

→

ethyl 3-amino-5-tert-butylbenzoate

Растворители

DCM

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated in vacuum
2. 2
   workup.DISSOLUTIONThe residue was dissolved in DCM
3. 3
   Экстракцияextracted with aqueous sodium bicarbonate solution
4. 4
   ДругоеThe organic layer was separated
5. 5
   Сушкаdried over sodium sulphate
6. 6
   Концентрированиеconcentrated in vacuum

Методика

Methyl 3-(tert.-butoxycarbonylamino)-5-tert-butylbenzoate (0.42 g) was dissolved in DCM (5 ml). To the resulting solution, TFA (1 ml) was added, the mixture was stirred for 30 min at room temperature and then concentrated in vacuum. The residue was dissolved in DCM and extracted with aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulphate and concentrated in vacuum to yield ethyl 3-amino-5-tert-butylbenzoate (0.28 g), which was used for the synthesis of example 112 without further purification.

Источник