Реакция #1509586

Уравнение реакции

2-Methyl-6-oxo-1,6-dihydro-pyridine-3-carbonitrile

POCl3

→

title compound

6-Chloro-2-methyl-nicotinonitrile

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 3 h
2. 2
   ДругоеThe reaction mixture was dried down in vacuum and ice
3. 3
   workup.ADDITIONwas added
4. 4
   ЭкстракцияThe aqueous layer was extracted with EtOAc
5. 5
   ДругоеThe organic layer was separated
6. 6
   Другоеdried
7. 7
   Концентрированиеconcentrated in vacuum

Методика

A mixture of 2-Methyl-6-oxo-1,6-dihydro-pyridine-3-carbonitrile (44 g) and POCl3 (250 ml) was refluxed for 3 h. The reaction mixture was dried down in vacuum and ice followed by conc. aqueous ammonia (300 ml) was added. The aqueous layer was extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum affording the title compound (23.5 g, BP (18 mbar) 119-120° C.).

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