Реакция #1502

Уравнение реакции

Chloromethyl chloroformate

cholesterol

Pyridine

→

3-(Chloromethoxycarbonyl) Cholesterol

Растворители

CH2Cl2

CH2Cl2

Условия реакции

Обработка

1. 1
   ТемператураThe solution was cooled
2. 2
   ТемператураHeat
3. 3
   Другоеwas produced
4. 4
   Другоеthe reaction gave a clear solution from
5. 5
   Промывкаwashed with 0.5M HCl (50 ml) and water (3×25 ml)
6. 6
   ДругоеAfter treatment with MgSO4, the solution was evaporated to dryness

Методика

Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.

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