Реакция #1491

Уравнение реакции

2-trimethylsilylethyl 4-[[(5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalen-2-yl)carbonyl]oxy]-benzoate

tetrabutylammonium fluoride

→

4-[[(5,5-Dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalen-2-yl)carbonyl]oxy]-benzoic acid

Растворители

THF

THF

EtOAc

Условия реакции

Обработка

1. 1
   Промывкаwashed with H2O and saturated aqueous NaCl
2. 2
   Сушкаbefore being dried over MgSO4
3. 3
   ДругоеThe solvents were removed under reduced pressure
4. 4
   Промывкаthe residue washed with hot acetonitrile leaving the product as a colorless solid

Методика

To a solution of 2-trimethylsilylethyl 4-[[(5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-naphthalen-2-yl)carbonyl]oxy]-benzoate (Compound E10, 100.0 mg, 0.198 mmol) in 2.0 mL THF at room temperature was added 155.3 mg of tetrabutylammonium fluoride (0.594 mmol 0.6 mL of a 1M solution in THF). After stirring overnight the reaction was diluted with EtOAc and washed with H2O and saturated aqueous NaCl before being dried over MgSO4. The solvents were removed under reduced pressure and the residue washed with hot acetonitrile leaving the product as a colorless solid.

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