Реакция #1490782

Уравнение реакции

4-methoxybenzylamine

methyl 2,4-difluoro-5-nitrobenzoate

DIEA

→

methyl 2-fluoro-4-(4-methoxybenzylamino)-5-nitrobenzoate

Выход 82.0%

Растворители

water

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ФильтрацияThe solids were collected by filtration

Методика

To a solution of methyl 2,4-difluoro-5-nitrobenzoate (35 g, 161.20 mmol) in N,N-dimethylformamide (1000 ml) was added DIEA (41.3 g, 319.56 mmol). Then (4-methoxybenzylamine (28.72 g, 209.64 mmol) was added dropwise with stirring for 1 hour at 25° C. The reaction mixture was diluted with water (2 L). The solids were collected by filtration to afford methyl 2-fluoro-4-(4-methoxybenzylamino)-5-nitrobenzoate as a yellow solid (44 g, 82%).

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