Реакция #1447093

Уравнение реакции

water

Sodium methoxide

(2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

sodium methoxide

→

(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

Растворители

DMF

Условия реакции

Обработка

1. 1
   workup.ADDITIONis added
2. 2
   Экстракцияthe resulting mixture is extracted with ethyl acetate
3. 3
   СушкаThe organic phase is dried (sodium sulphate)
4. 4
   Другоеthe solvent is removed
5. 5
   Другоеthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

Методика

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

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