Реакция #1447086

Уравнение реакции

D-Homophenylalanine hydrochloride

benzyl alcohol

p-toluenesulfonic acid monohydrate

→

title product

Выход 83.7%

D-Homophenylalanine Benzyl ester Tosylate

Выход 83.7%

Растворители

benzene

Условия реакции

Обработка

1. 1
   Температураat reflux in Dean Stark apparatus during 5 hrs
2. 2
   workup.DISTILLATIONafter which time additional benzene (100 mL) was distilled from reaction mixture
3. 3
   ДругоеThe residue was triturated with diethyl ether
4. 4
   Фильтрацияthe solid was filtered
5. 5
   Другоеdried

Методика

A solution of D-Homophenylalanine hydrochloride (1.7 g, 7.93 mmol), benzyl alcohol (7.2 mL, 64.0 mmol) and p-toluenesulfonic acid monohydrate (1.8 g, 9.5 mmol) in benzene (30 mL) was heated at reflux in Dean Stark apparatus during 5 hrs, after which time additional benzene (100 mL) was distilled from reaction mixture. The residue was triturated with diethyl ether, the solid was filtered and dried to give title product (2.93 g).

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