Реакция #1435746

Уравнение реакции

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine

thiocarbonyl diimidazole

water

→

[1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

Растворители

DMF

Условия реакции

Обработка

1. 1
   Экстракцияextracted with diethyl ether
2. 2
   СушкаThe extract was dried with sodium sulfate
3. 3
   Концентрированиеconcentrated
4. 4
   Другоеto give a pale yellow solid

Методика

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.

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