Реакция #1435726

Уравнение реакции

ammonium chloride

5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

4-methylpiperidine

→

5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

Выход 80.9%

Растворители

chloroform

Условия реакции

Обработка

1. 1
   ТемператураUnder ice-cooling
2. 2
   ПромывкаThe separated organic layer was washed with water
3. 3
   Сушкаdried over sodium sulfate
4. 4
   Концентрированиеconcentrated
5. 5
   ПромывкаThe residue was washed with t-butyl methyl ether

Методика

Under ice-cooling, 0.64 g of 5,7-dichloro-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine and 0.79 g of 4-methylpiperidine were mixed. The mixture was allowed to stand at room temperature for one hour, and chloroform and aqueous saturated ammonium chloride solution were added to the reaction mixture. The separated organic layer was washed with water, dried over sodium sulfate and concentrated. The residue was washed with t-butyl methyl ether to give 0.62 g of 5-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine

Источник