Реакция #1435725

Уравнение реакции

diethyl (2,4,6-trifluorophenyl)malonate

2-aminoimidazole hydrochloride

DBU

N,N-dimethylformamide

→

5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

Выход 78.3%

Растворители

water

chloroform

Условия реакции

Обработка

1. 1
   Температураto cool to room temperature
2. 2
   КонцентрированиеThe separated water layer was concentrated
3. 3
   workup.ADDITIONthe residue was diluted with water and conc. hydrochloric acid
4. 4
   workup.ADDITIONwas added
5. 5
   Температураunder ice-cooling
6. 6
   ДругоеThe precipitation
7. 7
   Фильтрацияwas filtered
8. 8
   Другоеdried

Методика

A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.

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