Реакция #1381

Уравнение реакции

Methyl 2-methyl-3-nitrobenzoate

→

methyl 2-methyl-3-aminobenzoate

Выход 101.6%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Другоеat room temperature
2. 2
   Фильтрацияthe catalyst is filtered off
3. 3
   КонцентрированиеThe reaction mixture is concentrated
4. 4
   workup.ADDITIONis added water
5. 5
   Экстракцияfollowed by extraction with dichloromethane
6. 6
   КонцентрированиеThe solvent is concentrated

Методика

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

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