Реакция #1367

Уравнение реакции

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

Выход 71.3%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияAfter the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   Экстракцияextracted with dichloromethane
4. 4
   СушкаThe is dried over magnesium sulfate
5. 5
   Концентрированиеconcentrated

Методика

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

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