Реакция #1350576

Уравнение реакции

3-methoxyphenylacetyl chloride

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

Выход 19.0%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl]-2-(3-methoxyphenyl)acetamide

Выход 19.0%

Растворители

dichloromethane

dichloromethane

brine

Условия реакции

Обработка

1. 1
   ПромывкаThe organic layer was washed with more brine
2. 2
   Сушкаthen dried over magnesium sulphate
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   ДругоеThe crude product was purified by column chromatography (ethyl acetate-toluene, 1:1)

Методика

A solution of 3-methoxyphenylacetyl chloride (0.02 ml, 0.12 mmol) in dichloromethane (0.75 ml) was added dropwise at 0° C. to a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (0.02 ml, 0.13 mmol) in dichloromethane (0.75 ml). The resulting mixture was stirred at room temperature for 16 h and then poured into brine. The organic layer was washed with more brine then dried over magnesium sulphate and concentrated in vacuo. The crude product was purified by column chromatography (ethyl acetate-toluene, 1:1), giving the title compound (9 mg, 19%). Rf 0.30 (ethyl acetate-toluene, 1:1).

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