Реакция #1340611

Уравнение реакции

hydrogen

(3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-vinylpyrrolidine

→

title compound

(3S)-3-(tert-Butoxycarbonyl)amino-4-ethylpyrrolidine

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtration
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure

Методика

A 10% palladium carbon catalyst (15 mg) was added to a solution of (3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-vinylpyrrolidine [an isomer mixture of (4S)-form:(4R)-form (1:4)] (230 mg, 0.66 mmol) in ethanol (8 mL), followed by stirring in a hydrogen atmosphere under an ordinary pressure at room temperature for 12 hours. After filtration, the filtrate was concentrated under reduced pressure, to thereby yield the title compound (an isomer mixture of (4S)-form and (4R)-form (1:4)) as a colorless oily substance (148 mg, 100%).

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