Реакция #1340608

Уравнение реакции

(3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-isopropenylpyrrolidine

hydrogen

→

(35)-3-(tert-Butoxycarbonyl)amino-4-isopropylpyrrolidine

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияAfter filtration
2. 2
   workup.ADDITIONa 10% palladium carbon catalyst (300 mg) was added again to the filtrate
3. 3
   ФильтрацияAfter filtration
4. 4
   Концентрированиеthe filtrate was concentrated under reduced pressure

Методика

A 10% palladium carbon catalyst (300 mg) was added to a solution of (3S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-isopropenylpyrrolidine (300 mg, 832 μmol) in methanol (10 mL), and the resultant mixture was stirred in a hydrogen atmosphere under an ordinary pressure for 2 hours. After filtration, a 10% palladium carbon catalyst (300 mg) was added again to the filtrate, followed by stirring in a hydrogen atmosphere under an ordinary pressure for 1 hour. After filtration, the filtrate was concentrated under reduced pressure, to thereby yield (3S)-3-(tert-butoxycarbonyl)amino-4-isopropylpyrrolidine as a colorless amorphous (172 mg, quantitative amount).

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