Реакция #1340587

Уравнение реакции

hydrochloric acid

N-[2,6-dibromo-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-phenyl]-3-nitro-4-(1,2,4-triazol-1-yl)benzamide

→

3-amino-N-[2,6-dibromo-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-phenyl]-4-(1,2,4-triazol-1-yl)benzamide

Выход 58.0%

Растворители

water

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered through a silica gel pad
2. 2
   Концентрированиеthe filtrate concentrated
3. 3
   ДругоеThe residue was purified by column chromatography on silica gel (eluent: cyclohexane/ethyl acetate 1:1)
4. 4
   Другоеto give Compound No

Методика

To a solution of N-[2,6-dibromo-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-phenyl]-3-nitro-4-(1,2,4-triazol-1-yl)benzamide (Example I2) (675 mg, 0.98 mmol) in a mixture of ethanol and water (20 ml and 4 ml, respectively) was added aqueous hydrochloric acid (37% w/v) (0.25 ml) and iron metal powder (5550 mg, 9.8 mmol). The reaction mixture was stirred at 80° C. for 1 hour. The mixture was filtered through a silica gel pad and the filtrate concentrated. The residue was purified by column chromatography on silica gel (eluent: cyclohexane/ethyl acetate 1:1) to give Compound No. B4 of Table B (372 mg, 58% yield).

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