Реакция #1340559

ord-f55902efc1bd48019226ba0005c98f2f

Уравнение реакции

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl
mometasone furoate monohydrate
[Cl-].[Na+]
NaCl
→
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl
mometasone

Реактанты

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)CCl
mometasone furoate monohydrate
—
suspension
[Cl-].[Na+]
NaCl

Реагенты

Нет

Растворители

O
water

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    workup.ADDITIONmixed thoroughly

Методика

A sample of the complexed mometasone furoate monohydrate stock suspension (4 g) was mixed with an appropriate diluent (27.2 g) (deionized water or saline (0.9% NaCl/deionized water (w/w)) and mixed thoroughly to obtain the 0.05% w/w mometasone formulations containing 0.097% HPMC, 0.002% sodium lauryl sulfate, 0.014% methylparaben sodium, 0.016% citric acid anhydrous, 0.009% potassium sorbate and approximately 0.5 ppm of 30% simethicone emulsion.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08455002B2uspto-grants-2013_06