Реакция #1328421

Уравнение реакции

potassium carbonate

3-bromopropionic acid

methyl 2-mercapto-4-chlorobenzoate

→

Methyl 2-(2-hydroxycarbonyleth-1-yl)thio-4-chlorobenzoate

Растворители

acetone

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   Экстракцияthe mixture was extracted with diethyl ether
3. 3
   Фильтрацияthe resulting precipitate was filtered off with suction
4. 4
   Другоеdried

Методика

179.5 g (1.3 mol) of potassium carbonate and, a little at a time, 94.5 g (0.62 mol) of 3-bromopropionic acid were added to a solution of 125.4 g (0.62 mol) of methyl 2-mercapto-4-chlorobenzoate in 1.5 l of acetone, and the reaction mixture was stirred at room temperature for 12 hours. The solvent was distilled off, the residue was taken up in water and the mixture was extracted with diethyl ether. The aqueous phase was then made acidic using concentrated hydrochloric acid, and the resulting precipitate was filtered off with suction and dried. This gave 150 g (88%) of methyl 2-(2-hydroxycarbonyleth-1-yl)thio-4-chlorobenzoate.

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