Реакция #1328420

Уравнение реакции

methyl 2-chlorosulfonyl-4-chlorobenzoate

→

Methyl 2-mercapto-4-chlorobenzoate

Растворители

hydrochloric acid

—

ice

Условия реакции

Обработка

1. 1
   workup.WAITAfter 2 hours at this temperature
2. 2
   Температураthe mixture was cooled
3. 3
   workup.WAITto stand at room temperature for 12 hours
4. 4
   Экстракцияextracted with ethyl acetate
5. 5
   Другоеthe combined organic phases were dried
6. 6
   Другоеthe solvent was removed

Методика

Over a period of 1.5 hours, 243.5 g (3.7 mol) of zinc powder were added a little at a time to a suspension of 205 g (0.75 mol) of methyl 2-chlorosulfonyl-4-chlorobenzoate in 1 l of concentrated hydrochloric acid and 375 g of ice. The mixture was stirred for another 3 hours and slowly heated to 70° C. After 2 hours at this temperature, the mixture was cooled. The reaction mixture was allowed to stand at room temperature for 12 hours and then extracted with ethyl acetate, the combined organic phases were dried and the solvent was removed. This gave 125.4 g (83%) of methyl 2-mercapto-4-chlorobenzoate.

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