Реакция #1275

Уравнение реакции

sodium hydroxide

sulfuric acid

Trans-1,2-indandiol

acetonitrile

acetonitrile

Water

→

cis-1-amino-2-indanol

Выход 63.0%

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was gradually warmed to 20° C. and aged to 3 hours
2. 2
   Температураthe mixture heated to reflux
3. 3
   ДругоеThe resulting solid was removed by filtration

Методика

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

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