Реакция #1269863

Уравнение реакции

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

Растворители

Et2O

CH2Cl2

Условия реакции

Обработка

1. 1
   Фильтрацияthe white cake was filtered
2. 2
   Промывкаwashed with Et2O
3. 3
   Другоеdried at HV overnight
4. 4
   ДругоеThe crude (1.19 g) was used without purification

Методика

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

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