Реакция #1269852

Уравнение реакции

4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester

2-phenyl-1,3-thiazole-4-carboxylic acid

DIPEA

TBTU

→

desired product

Выход 49.0%

4-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid ethyl ester

Выход 49.0%

Растворители

DMF

DMF

DMF

Условия реакции

Обработка

1. 1
   Другоеthe reaction mixture was directly purified by preparative HPLC (IV)

Методика

To a solution of 2-phenyl-1,3-thiazole-4-carboxylic acid (5.1 mg) and DIPEA (3 eq) in DMF (0.4 mL) was added TBTU (1.2 eq) in DMF (0.2 mL). Then, a solution of 4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester (5.4 mg, prepared as described in WO2006114774) in DMF (0.2 mL) was added. After stirring overnight at RT, the reaction mixture was directly purified by preparative HPLC (IV) to give 4.9 mg of the desired product.

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