Реакция #1269843

Уравнение реакции

DBU

BOP

3-Methyluracil

(1R,2R)-(−)-2-hydroxycyclopentylamine hydrochloride salt

→

product

Выход 76.5%

2-((1R,2R)-2-hydroxycyclopentylamino)-3-methylpyrimidin-4(3H)-one

Выход 76.5%

Растворители

DMF

Условия реакции

Обработка

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature overnight
2. 2
   ДругоеThe reaction mixture was purified by a semi-preparative HPLC

Методика

3-Methyluracil (12.6 mg, 0.1 mmol) was dissolved in 0.5 mL of DMF, and then BOP (71 mg, 0.16 mmol) was added. The mixture was stirred at room temperature for two minutes, then (1R,2R)-(−)-2-hydroxycyclopentylamine hydrochloride salt (22 mg, 0.16 mmol) was added, followed by DBU (51 uL, 3.4 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was purified by a semi-preparative HPLC to give pure product (16 mg, yield 76%). MS (ESI) m/z 210.1 [M+H]+.

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