Реакция #1269838

Уравнение реакции

ethyl acrylate

ethyl glycinate hydrochloride

sodium hydroxide

→

Diethyl-2-azabutane-1,4-dicarboxylate

Растворители

water

Условия реакции

Обработка

1. 1
   ДругоеAfter 19 h the solution is partitioned with dichloromethane (3×100 mL)
2. 2
   СушкаThe organic layer is dried with anhydrous sodium sulfate
3. 3
   Фильтрацияfiltered
4. 4
   Другоеevaporated
5. 5
   workup.DISTILLATIONThe residue is distilled
6. 6
   Другоеto afford AA (28.8 g, 61%)

Методика

A 4.7 M aqueous solution of sodium hydroxide (50 mL) is added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) is added and the mixture is stirred at room temperature until completion of the reaction is ascertained by TLC. After 19 h the solution is partitioned with dichloromethane (3×100 mL). The organic layer is dried with anhydrous sodium sulfate, filtered and evaporated. The residue is distilled to afford AA (28.8 g, 61%).

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