Реакция #1256761

Уравнение реакции

trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-{4-[3-(2-fluoro-phenyl)-ureido]-phenyl}-pyridin-2-yl ester

hydrazine hydrate

→

product

Выход 26.0%

1-[4-(3-amino-6-cyclopropyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-phenyl]-3-(2-fluoro-phenyl)-urea

Выход 26.0%

Растворители

1-propanol

Условия реакции

Методика

In analogy to the GP 5, reaction of 175 mg trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-{4-[3-(2-fluoro-phenyl)-ureido]-phenyl}-pyridin-2-yl ester (0.336 mmol) with 62 μl 80% hydrazine hydrate in 1-propanol yielded 35 mg product (0.087 mmol, 26% yield).

Источник