Реакция #1256758

Уравнение реакции

ammonium acetate

methyl cyanoacetate

1-cyclopropyl-ethanone

4-nitrobenzaldehyde

→

product

Выход 35.0%

6-Cyclopropyl-4-(4-nitro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Выход 35.0%

Условия реакции

Методика

Reaction of 17.9 g ammonium acetate (233 mmol, 7 eq.), 3.5 ml methyl cyanoacetate (40 mmol, 1.2 eq.), 3.8 ml 1-cyclopropyl-ethanone (38 mmol, 1.15 eq.), and 5 g 4-nitrobenzaldehyde (33 mmol, 1 eq.) yielded 3.23 g product (11.5 mmol, 35% yield).

Источник