Реакция #1256751

Уравнение реакции

ammonium chloride

Magnesium

iodine

diisopropylchlorosilane

1-Bromo-3-ethoxypropane

→

liquid

Выход 107.4%

(3-Ethoxypropyl)diisopropylsilane

Выход 107.4%

Растворители

THF

THF

Условия реакции

Обработка

1. 1
   Экстракцияthe resultant mixture was extracted with pentane
2. 2
   Промывкаby washing with water six times
3. 3
   Сушкаdrying over sodium sulfate anhydrate
4. 4
   ДругоеThe solvent was removed under reduced pressure, whereby the Compound 61a

Методика

1-Bromo-3-ethoxypropane (5.85 g, 35.0 mmol) was dissolved in THF (30 mL). Magnesium (900 mg, 37.0 mmol) and iodine (catalytic amount) were added thereto, and the resultant mixture was stirred at room temperature for 30 minutes and at 60° C. for 10 minutes. The resultant mixture was added dropwise to diisopropylchlorosilane (5.12 mL, 30.0 mmol) in THF (40 mL), followed by stirring at room temperature for 15 minutes and at 60° C. for 1.5 hours. Saturated aqueous ammonium chloride was added thereto, and the resultant mixture was extracted with pentane, followed by washing with water six times and drying over sodium sulfate anhydrate. The solvent was removed under reduced pressure, whereby the Compound 61a was obtained as an yellow liquid (6.52 g, 92%).

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