Реакция #1256734

Уравнение реакции

[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile

di-terbutyl carbonate

Sodium borohydride

→

tert-butyl {2-[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]ethyl}carbamate

Растворители

methanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONis added portionwise to the reaction mixture
2. 2
   Другоеis allowed to room temperature

Методика

The [1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile (4.76 mmol, 0.90 g), the di-terbutyl carbonate (9.52 mmol, 2.08 g) and nickel chloride hexahydrate (4.77 mmol, 1.13 g) are added to methanol (10 ml) at room temperature. Sodium borohydride (13.1 mmol, 0.49 g). is added portionwise to the reaction mixture. The reaction mixture is allowed to room temperature and stirred for three hours.

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