Реакция #1246187

Уравнение реакции

2′,6′-Difluoroacetophenone

hydrazine

water

→

title compound

Выход 85.0%

4-fluoro-3-methyl-1H-indazole

Выход 85.0%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Другоеby irradiating microwaves
2. 2
   Другоеterminated
3. 3
   Другоеthe reaction
4. 4
   Промывкаwashed with water
5. 5
   СушкаThe organic layer was dried over anhydrous magnesium sulfate
6. 6
   Концентрированиеconcentrated
7. 7
   Другоеvacuum evaporation
8. 8
   ДругоеThe residue was re-crystallized in dichloromethane

Методика

2′,6′-Difluoroacetophenone (0.468 g, 3 mmol) was dissolved in anhydrous hydrazine (2 ml), followed by irradiating microwaves thereon with stirring at 150° C. for 5 min. The addition of water (0.5 ml) at 0° C. terminated the reaction. Afterwards, the reaction solution was diluted with ethyl acetate (10 ml) and washed with water. The organic layer was dried over anhydrous magnesium sulfate and concentrated using vacuum evaporation. The residue was re-crystallized in dichloromethane to give the title compound (Yield 85%).

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