Реакция #1244278

Уравнение реакции

alkyne

2-Nitro-1-(prop-2-ynyl)-1H-imidazole

29

2-Azido-3-fluoropropan-1-ol

→

1

3-Fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol

Условия реакции

Обработка

1. 1
   ДругоеThe material is then purified on a silica gel column
2. 2
   ДругоеThe material is then further purified via recrystallization

Методика

To a vial is added alkyne 10 (1.9 g, 12.6 mmol) and 29 (1.5 g, 12.6 mmol). The solution is heated at 60° C. overnight. The material is then purified on a silica gel column using 10% MeOH:CH2Cl2 as the eluent. The material is then further purified via recrystallization using EtOAc:Hex to afford 1 as a solid.

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