Реакция #1233

Уравнение реакции

3-methyl-4-iodobenzoic acid

methanol

sulfuric acid

→

methyl 3-methyl-4-iodobenzoate

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated
2. 2
   Температураat reflux for twelve hours
3. 3
   Другоеthe reaction medium evaporated
4. 4
   Другоеwater, the organic phase decanted off
5. 5
   Сушкаdried over magnesium sulfate
6. 6
   Другоеevaporated
7. 7
   ДругоеThe residue was triturated in methanol
8. 8
   Фильтрацияfiltered
9. 9
   Другое21.9 g (85%) of the expected methyl ester of melting point 58°-59° C. were recovered

Методика

24.4 g (0.093 mol) of 3-methyl-4-iodobenzoic acid and 250 ml of methanol were introduced into a round-bottomed flask and 2.5 ml of concentrated sulfuric acid were added dropwise. The mixture was heated at reflux for twelve hours, the reaction medium evaporated, taken up in ethyl acetate and water, the organic phase decanted off, dried over magnesium sulfate and evaporated. The residue was triturated in methanol and filtered; 21.9 g (85%) of the expected methyl ester of melting point 58°-59° C. were recovered.

Источник