Реакция #1224

Уравнение реакции

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

Растворители

water

ethyl ether

Условия реакции

Обработка

1. 1
   Другоеthe reaction medium evaporated to dryness
2. 2
   Другоеthe residue obtained
3. 3
   ДругоеThe organic phase was decanted off
4. 4
   Сушкаdried over magnesium sulfate
5. 5
   Другоеevaporated
6. 6
   ДругоеThe residue obtained
7. 7
   Другоеwas triturated in heptane
8. 8
   Фильтрацияfiltered
9. 9
   Другое4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

Методика

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

Источник