Реакция #1192

Уравнение реакции

2-ethylhexyl bromide

1,10-decanediol

KOH

→

10-(2-ethylhexyloxy)decanol

Выход 72.1%

Растворители

xylene

Условия реакции

Обработка

1. 1
   ДругоеA 1-liter flask equipped with a stirrer
2. 2
   workup.DISTILLATIONdistilling off water
3. 3
   Другоеformed
4. 4
   Температураthe resulting mixture was heated
5. 5
   ДругоеAfter completion of the reaction
6. 6
   Промывкаwashed with water
7. 7
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
8. 8
   Другоеthe resulting residue was purified by column chromatography on silica gel

Методика

A 1-liter flask equipped with a stirrer and distiller was charged with 25 g (0.14 mol) of 1,10-decanediol, 8.09 g (0.14 mol) of KOH and 300 ml of xylene, and the resultant mixture was heated at 120° C. for 1 hour, thereby distilling off water formed. To this reaction mixture, were added 23.1 g (0.12 mol) of 2-ethylhexyl bromide, and the resulting mixture was heated and stirred for 15 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and washed with water. After the solvent was distilled off under reduced pressure, the resulting residue was purified by column chromatography on silica gel, thereby obtaining 24.8 g (yield: 72%) of 10-(2-ethylhexyloxy)decanol.

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