Реакция #11903

Уравнение реакции

trityl candesartan cilexetil

methanol

→

candesartan cilexetil

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwas gently refluxed for about 16–17 h
2. 2
   ДругоеThe solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C.

Методика

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), methanol (200 ml), and water (1 ml) was gently refluxed for about 16–17 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue.

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