Реакция #11901

Уравнение реакции

trityl candesartan cilexetil

toluene

methanol

→

candesartan cilexetil

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwas gently refluxed for about 12 h
2. 2
   ДругоеThe solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C

Методика

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), toluene (60 ml), methanol (60 ml), and water (1 ml) was gently refluxed for about 12 h. The reaction was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. 60° C. to obtain viscous oil of candesartan cilexetil as a residue (36.5 g).

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