Реакция #1184

Уравнение реакции

1-fluoro-2-methyl-4-nitrobenzene

hydrazine hydrate

hydrazine hydrate

→

expected product

1-Hydrazino-2-methyl-4-nitrobenzene hydrofluoride

Растворители

2-propanol

Условия реакции

Обработка

1. 1
   Температураis heated
2. 2
   Температураto reflux for 2 hours
3. 3
   Температураrefluxing
4. 4
   workup.WAITthe mixture is left overnight
5. 5
   ДругоеThe precipitate formed

Методика

A mixture of 4.6 g of 1-fluoro-2-methyl-4-nitrobenzene and 3 ml of hydrazine hydrate in 45 ml of 2-propanol is heated to reflux for 2 hours. 3 ml of hydrazine hydrate are added, refluxing is continued for 2 hours and the mixture is left overnight with stirring at RT. The precipitate formed is drained. 3.53 g of the expected product are obtained, m.p.=182° C.

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