Реакция #11798

Уравнение реакции

2-(4-chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

cesium carbonate

bromoacetonitrile

→

title compound

Выход 102.8%

(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenoxy)-acetonitrile

Выход 102.8%

Растворители

dioxane

ethyl acetate

Условия реакции

Обработка

1. 1
   Промывкаwashed with water
2. 2
   ПромывкаThe organic layer was washed with saturated aqueous sodium chloride
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   Концентрированиеconcentrated in vacuo

Методика

To a solution of 2-(4-chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone (0.10 g, 0.24 mmol), and cesium carbonate (0.12 g, 0.38 mmol) in dioxane (1 mL) was added bromoacetonitrile (0.034 g, 0.28 mmol). The resulting mixture was stirred at ambient temperature overnight. The reaction was diluted with ethyl acetate and washed with water. The organic layer was washed with saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated in vacuo to give the title compound (0.11 g).

Источник