Реакция #1178404

Уравнение реакции

4-Benzoylbenzoic acid

thionyl chloride

toluene

→

4-Benzoylbenzoyl Chloride

Выход 91.0%

Растворители

Dimethylformamide

Условия реакции

Обработка

1. 1
   Другоеequipped
2. 2
   Температураwith reflux condenser and overhead stirrer
3. 3
   Температураthe mixture was heated
4. 4
   Температураat reflux for 4 hours
5. 5
   ТемператураAfter cooling
6. 6
   Другоеthe solvents were removed under reduced pressure
7. 7
   Другоеthe residual thionyl chloride was removed by three evaporations
8. 8
   ДругоеThe product was recrystallized from 1:4 toluene
9. 9
   Другоеhexane to give 988 g (91% yield)
10. 10
    Другоеafter drying in a vacuum oven
11. 11
    ДругоеThe final compound was stored for use in the preparation of a monomer

Методика

4-Benzoylbenzoic acid (BBA), 1.0 kg (4.42 moles), was added to a dry 5 liter Morton flask equipped with reflux condenser and overhead stirrer, followed by the addition of 645 ml (8.84 moles) of thionyl chloride and 725 ml of toluene. Dimethylformamide, 3.5 ml, was then added and the mixture was heated at reflux for 4 hours. After cooling, the solvents were removed under reduced pressure and the residual thionyl chloride was removed by three evaporations using 3×500 ml of toluene. The product was recrystallized from 1:4 toluene:hexane to give 988 g (91% yield) after drying in a vacuum oven. Product melting point was 92-94° C. Nuclear magnetic resonance (NMR) analysis (1H NMR (CDCl3)) was consistent with the desired product: aromatic protons 7.20-8.25 (m, 9H). All chemical shift values are in ppm downfield from a tetramethylsilane internal standard. The final compound was stored for use in the preparation of a monomer used in the synthesis of Compound III.

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