Реакция #11765

Уравнение реакции

(5-chloro-2-methoxy-phenyl)-methanesulfonamide

boron tribromide

→

title compound

Выход 86.8%

(5-Chloro-2-hydroxy-phenyl)-methanesulfonamide

Выход 86.8%

Растворители

dichloroethane

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was quenched with water, saturated with sodium chloride
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   СушкаThe organic layer was dried over sodium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated

Методика

To a suspension of (5-chloro-2-methoxy-phenyl)-methanesulfonamide (0.03 g, 0.13 mmol) in dichloroethane (1.5 mL) was added boron tribromide solution (1M in dichloromethane, 0.26 mL, 0.26 mmol). The reaction was stirred for one hour at ambient temperature. The reaction was quenched with water, saturated with sodium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to give the title compound (0.025 g).

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